The case is presented a 49-year-old man had several year history with chronic renal failure with hyperlipidemia due to diabetes mellitus. Treatment of hyperlipidemia was started by oral bezafibrate intake 600 mg per day. Several days later,
patient
noticed muscle weakess and myalgia. The serum CK, LDH, AST levels were remarkably elevated, myoglobulinuria was also noticed. The symptoms of the patient were resolved after the drug was discontinued, thus the diagnosis was established as having
bezafibrate induced rhabdomyolysis. On the basis of the above description, bezafibrate may induce muscle damage if dose is excess over the renal capacity. Extreme caution is warranted when the patient is placed on bezafibrate and has renal
dysfunction.
Strict dose adjustment is necessary in taking account of renal function to avoid muscle damage including rhabdomyolysis. (J Kor Soc Endocrinol 9: 50~53, 1994)
|